Thus, it can be conceivable the JIP1/3???ASK1???MKK4 signaling module might function a conduit to activate JNK when endosomal trafficking is disrupted and glucose ranges tumble throughout the early stages of methuosis. Our getting that MKK4 was robustly activated from the methuosis-inducing IPPs, MOMIPP and 2q, and fewer so by the non-cytotoxic vac